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With the increasing number of Taiwan's adult patients having undergone hematopoietic stem cell transplantation (HSCT), the medical care for these patients is no longer limited to the hospital. Their homes are often the care providers. The purpose of this study was to evaluate the end-of-life experience of non-hematopoietic stem cell transplantation (non-HSCT) patients in their homes. Semistructured interviews were conducted with 35 non-HSCT survivors and 30 of their caregivers. The interviews focused on the end-of-life experience from the caregivers' perspectives. The study revealed that most of the non-HSCT recipients were older than 35 years and lived with their spouse. Most had been in a good physical condition at the end of life, but most needed a family member to provide them with symptom control. Because of the nature of the illness, the medical trajectory of non-HSCT survivors was different from that of HSCT patients. From the caregivers' perspectives, the challenges they faced included the need for a commitment to care for patients to the end of life, the need to have sufficient knowledge of patients' conditions, and the need for the caregivers' freedom to be able to make end-of-life decisions for 0b46394aab