Giant cell granuloma is a common reactive lesion of the jaw bone. It has also been referred to as a'reactive periosteal hyperplasia' or 'peripheral ossifying fibroma'. Peripheral giant cell granuloma is not a true neoplasm and it rarely behaves aggressively. The most common presentation of peripheral giant cell granuloma is as a painless, asymptomatic lesion of the gingiva. Also, some other non-odontogenic tumors such as osteosarcoma, chondroma, fibroma, and osteoma can resemble peripheral giant cell granuloma.
Peripheral giant cell granuloma can occur at any age but it is more common in younger age groups and at advanced stage. It is common in females, and a high proportion of patients with this condition are otherwise healthy. The cause of peripheral giant cell granuloma is unknown and it is thought to be a reactive lesion.
Peripheral giant cell granuloma is a relatively common benign exophytic lesion of the gingiva and alveolar ridge that originates from the connective tissue and can be associated with local trauma. Peripheral giant cell granuloma is usually described as small and with a dome-shaped, hard surface that is sometimes sessile and firm.
Peripheral giant cell granuloma is often asymptomatic, with the most common symptom being a painless or painful swelling. It may also be associated with oral hygiene difficulties or bleeding.
It is often found in the mandible, and the gingiva and alveolar ridge of the maxilla are the two most common locations. Occasionally, it may develop in the palate. The tumor can grow rapidly and may become very large. It may also spread locally and also extend to adjacent bone.
Peripheral giant cell granuloma may be associated with tooth crowding, mobility, and caries. It may also cause irritation and trauma to the adjacent tissues, and may lead to dental abscess formation.
The origin of peripheral giant cell granuloma is thought to be the connective tissue of the periodontium, and it has been described as a localized form of heterotopic ossification.(CNN) People who experience a common symptom of Alzheimer's disease -- the recall of an event that occurred during childhood -- have been found to harbor one gene variant for two to five times more often than people 0b46394aab